What is D Plus used for?

A: D Plus is a high-strength Vitamin D dietary supplement delivering 5,000 IU of Vitamin D3 (cholecalciferol) combined with 150 mcg of Vitamin K2 (MK-4) per tablet. It is formulated to provide high-strength Vitamin D3 support for adults with increased needs, for use under healthcare professional guidance supporting immune function, bone mineralisation, mood stability, and muscle health, particularly during the UK's autumn and winter months when sunlight synthesis is insufficient.

Why is Vitamin K2 included with Vitamin D3?

A: Vitamin D3 increases calcium absorption from food. Without adequate Vitamin K2, that additional calcium circulates without clear direction and has been associated with arterial calcification when left unmanaged. Vitamin K2 (as MK-4) activates two proteins that govern calcium distribution: osteocalcin, which binds calcium into bone matrix, and matrix GLA protein (MGP), which prevents calcium from depositing in arterial walls. At a therapeutic dose of 5,000 IU D3, K2 is not optional. it is the co-factor that makes high-dose D3 supplementation both safe and complete.

Is 5,000 IU of Vitamin D3 safe to take daily?

A: For most adults, yes u2014 particularly those with confirmed deficiency or insufficiency. The UK's Tolerable Upper Intake Level for Vitamin D is 4,000 IU per day for general supplementation, but clinical evidence supports higher doses in deficient individuals under medical guidance. If you have concerns about your Vitamin D status, a serum 25(OH)D blood test before starting will establish your baseline and allow you and your healthcare provider to determine the appropriate dose for your individual situation. People with certain conditions including hypercalcaemia or granulomatous disorders should not supplement at high doses without medical supervision.

What is the difference between Vitamin D2 and Vitamin D3?

Vitamin D3 (cholecalciferol) is the form the skin produces during sunlight exposure and is the form used in D Plus. Research consistently shows that D3 raises serum 25(OH)D levels approximately three times more effectively than D2 (ergocalciferol) at equivalent doses, and produces more stable, longer-lasting blood levels. D2 is plant-derived and used in some supplements and fortified foods u2014 but for therapeutic blood level optimisation, D3 is the clinically superior form.

When is the best time to take D Plus?

A: Take one tablet daily with a meal containing dietary fat u2014 morning is the most practical anchor for most people. Vitamin D3 is fat-soluble and requires dietary fat for optimal intestinal absorption. Taking it on an empty stomach or with a fat-free meal can significantly reduce the amount absorbed. Morning dosing also avoids the rare possibility that high-dose Vitamin D taken late in the day may interact with melatonin production and affect sleep quality.

How long does it take for Vitamin D3 supplementation to raise blood levels?

A: With consistent daily supplementation at 5,000 IU, most adults see a meaningful rise in serum 25(OH)D within four to eight weeks. Reaching optimal levels u2014 typically 40 - 60 ng/mL -- from a significantly deficient baseline may take two to three months of consistent use. The rate of increase depends on your starting level, body weight, dietary fat intake at the time of dosing, and individual absorption efficiency. A follow-up blood test at three months gives you an accurate picture of your response.

Is D Plus suitable for vegetarians?

A: The Vitamin D3 (cholecalciferol) in D Plus is derived from lanolin (sheep wool), which is an animal-derived source. D Plus is therefore not suitable for vegans. Vegetarians who consume animal by-products may consider it acceptable u2014 but should review the source if this is a concern. The tablet shell and other ingredients are plant-derived.

Where can I buy D Plus in the UK?

A: D Plus is available directly from Care & Cure Nutraceuticals at www.careandcure.co.uk. It is manufactured in the USA to GMP-certified standards and dispatched from London, UK.

Energy & Fatigue

D Plus High-Strength Vitamin D3 + K2 MK-4 Supplement

Name: D Plus™ Vitamin D3 5000 IU K2 MK-4 Supplement | 60 Tablets
Brand: Care and Cure Nutraceuticals Ltd.
SKU: CC-Vit-D
Price: 15 GBP
Availability: InStock
Rating: 4.9 (5 reviews)

5,000 IU Vitamin D3 (cholecalciferol) per tablet — a high-strength daily serving recommended for use under healthcare professional guidance, particularly where Vitamin D status has been assessed through blood testing
150 mcg Vitamin K2 (as MK-4) per tablet —supports the maintenance of normal bones alongside Vitamin D3, providing the co-factor that high-strength D3 supplementation calls for.
Immune system support — Vitamin D3 contributes to the normal function of the immune system.
Bone mineralisation support — D3 increases calcium absorption, K2 MK-4 ensures it reaches bone matrix via osteocalcin activation.
Seasonal support —Vitamin D levels in the UK tend to decline through autumn and winter, making consistent supplementation particularly relevant during those months.
Turmeric Extract botanical addition — included as part of a clean, additive-free formulation alongside Vitamin D3, which contributes to the normal function of the immune system.

£ 15.00

Buy 3 Get 1 Free

SKU CC-Vit-D

Vegetarian

Product Features & Quality Assurance

• GMP Certified — consistent quality and potency guaranteed across every batch
• Made in the USA — manufactured to pharmaceutical-grade standards
• Quality and Potency Guaranteed — no artificial colours, no preservatives
• Tablet format — easy to chew or swallow, with natural flavour from Xylitol and Stevia
• Clean formulation — blood-glucose neutral sweeteners, Turmeric Extract, no artificial additives
• 60 tablets — a full two-month supply at one tablet per day

D Plus™ is a high-strength Vitamin D dietary supplement delivering 5,000 IU of Vitamin D3 (as cholecalciferol) combined with 150 mcg of Vitamin K2 (as MK-4) in a single daily tablet. Each bottle contains 60 tablets — a full two-month supply — formulated with Xylitol, Fructooligosaccharides, Turmeric Extract, Stevia, and Natural Flavor to support palatability and a clean ingredient profile free from artificial additives. Cholecalciferol is the form of Vitamin D3 produced by the skin during sunlight exposure and is the most bioavailable oral form for raising serum 25(OH)D levels. MK-4 is the short-chain menaquinone form of Vitamin K2 with rapid tissue uptake and the most established clinical evidence for bone and cardiovascular safety in combination with high-dose Vitamin D3. D Plus™ pairs both at clinically relevant doses in a single convenient tablet.

Vitamin D insufficiency is the most prevalent nutritional deficiency in the UK adult population — and the gap between standard low-dose supplementation and genuine blood level optimisation is wider than most people appreciate. You may benefit from D Plus™ if you experience any of the following:

Indoor-based routines, limited time outdoors, or lifestyle factors that reduce the body's natural opportunity to produce Vitamin D.
Frequent infections, slow immune recovery, or reduced resilience during autumn and winter.
Autumn and winter months, when sunlight in the UK is insufficient for the skin to produce meaningful amounts of Vitamin D.
Bone density concerns, muscle weakness, or a history of stress fractures.
Limited sun exposure due to indoor work, northern UK location, or habitual sun protection use.
Darker skin tone — which requires significantly longer sun exposure to synthesise equivalent Vitamin D.
Age over 40, when both skin synthesis efficiency and renal activation of Vitamin D decline.
A confirmed or suspected Vitamin D deficiency identified through blood testing.

D Plus™ is built around the understanding that Vitamin D optimisation is a two-compound challenge. Raising serum Vitamin D levels with D3 alone addresses one side of the equation. Ensuring that the calcium mobilised by that D3 is directed appropriately requires K2. The formula delivers both at doses that make a measurable difference. Vitamin D3 at 5,000 IU is a high-strength serving for adults where a standard daily dose may not be sufficient. — The UK government’s standard recommendation of 400 IU is designed to prevent deficiency in the general population, not to optimise function in adults who are already depleted. Research consistently shows that adults with low baseline levels require significantly higher doses to reach the 25(OH)D blood levels — typically 40–60 ng/mL — associated with optimal immune, bone, and hormonal function. At 5,000 IU, D Plus™ provides the dose range that meaningfully moves the needle for deficient adults. This is the gap that 400 IU supplements do not close. Cholecalciferol is the form that matters for serum level optimisation — Vitamin D3 (cholecalciferol) raises serum 25(OH)D levels approximately three times more effectively than Vitamin D2 (ergocalciferol) at equivalent doses. The difference is not marginal. Studies comparing D2 and D3 supplementation consistently show that D3 produces higher, more stable blood levels and longer-lasting tissue stores. D Plus™ uses cholecalciferol exclusively — the same form the skin produces — ensuring that every 5,000 IU tablet delivers the biological equivalent of meaningful sunlight exposure. Vitamin K2 MK-4 at 150 mcg directs calcium where it belongs — High-dose Vitamin D3 increases intestinal calcium absorption. Without adequate Vitamin K2, that calcium enters the bloodstream without clear direction — and elevated unbound calcium has been associated with arterial calcification and reduced vascular flexibility. Vitamin K2 activates two critical proteins: osteocalcin, which binds calcium into bone matrix, and matrix GLA protein (MGP), which inhibits calcium deposition in arterial walls. MK-4 is the form with the fastest tissue uptake and the most established mechanistic evidence for this dual protective role. The D3-K2 combination supports immune regulation beyond bone and calcium — Vitamin D receptors are present in virtually every immune cell type, including T cells, B cells, macrophages, and dendritic cells. Vitamin D3 at optimised serum levels modulates both innate and adaptive immunity — enhancing pathogen defence while reducing the excessive inflammatory responses that drive autoimmune activity. This is why Vitamin D3 contributes to the normal function of the immune system — the authorised basis for its role in supporting immune health throughout the year, and particularly through autumn and winter. K2 contributes independently through its role in reducing vascular inflammation. Turmeric Extract adds complementary anti-inflammatory support — The inclusion of Turmeric Extract in the D Plus™ formula goes beyond flavouring. Turmeric, the botanical source of curcumin, is included in the D Plus™ formula as a well-researched plant extract with a long history of use in traditional wellness practices worldwide. In the context of a Vitamin D supplement, this is a meaningful addition: chronic low-grade inflammation impairs Vitamin D receptor sensitivity, reducing the cellular response to D3 even when serum levels improve. Turmeric addresses this receptor-level constraint directly. Xylitol and Stevia support palatability without blood sugar impact — D Plus™ is formulated as a tablet rather than a capsule, using Xylitol and Stevia as natural sweeteners alongside Natural Flavor. This makes the tablet easy to chew or dissolve if preferred — particularly relevant for adults who have difficulty swallowing capsules. Neither Xylitol nor Stevia raises blood sugar, making D Plus™ suitable for people managing blood glucose levels alongside their Vitamin D supplementation.

Active Ingredients: Vitamin D-3 (as cholecalciferol) 5,000 IU, Vitamin K-2 (as MK-4) 150 mcg. Other Ingredients: Xylitol, Fructooligosaccharides, Magnesium Stearate, Microcrystalline Cellulose, Natural Flavor, Stevia Extract (leaf), Turmeric Extract. No artificial colours. No preservatives. Quality and Potency Guaranteed.

Take 1 tablet daily, or as directed by your healthcare professional. For best results, take with a meal containing dietary fat — Vitamin D3 is fat-soluble and absorbs significantly more effectively when consumed alongside fat-containing food. Do not exceed the recommended daily intake unless advised by your doctor.

Do not use if the tamper-evident seal is broken or missing. Keep out of reach of children. Store tightly closed in a cool, dry place. Warning: Do not use this product if you are pregnant, nursing, or have a history of allergies without first consulting your doctor or other healthcare professional. If you are taking anticoagulant (blood thinning) medications, consult your physician before use as Vitamin K2 interacts with anticoagulant activity.

Serving Size: 1 Tablet | Servings per Container: 60

Ingredient	Amount	% DV
Vitamin D-3 (as cholecalciferol)	5,000 IU	1,250%
Vitamin K-2 (as MK-4)	150 mcg	*

*Daily Value (DV) not established.

Customer Reviews

5.0 5 reviews

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Parveen

★ ★ ★ ★ ★

9 May 2026

Very good increases energy level in short time well worth taking it definitely helps

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muhammadriazr915

★ ★ ★ ★ ★

10 March 2026

After trying several Vitamin D3 supplements with weak results, I finally found one that actually works. **D Plus Vitamin D3** has made a noticeable difference for me. The results have been much better compared to other supplements I’ve used, and I’m very satisfied with it. If you’re looking for an effective Vitamin D3 supplement, this one is definitely worth trying.

✅ Verified Purchase

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