Bone & Joint Health
D Plus Vitamin D3 5000 IU + K2 MK-4 Supplement | 60 Tablets
- 5,000 IU Vitamin D3 (cholecalciferol) per tablet — therapeutic dose that meaningfully raises deficient blood levels where low-dose supplements fall short.
- 150 mcg Vitamin K2 (as MK-4) per tablet — directs calcium into bone rather than arteries, the essential co-factor high-dose D3 requires.
- Immune regulation support — Vitamin D3 at optimised serum levels modulates both innate and adaptive immune response.
- Bone mineralisation support — D3 increases calcium absorption, K2 MK-4 ensures it reaches bone matrix via osteocalcin activation.
- Cardiovascular safety co-factor — K2 MK-4 inhibits arterial calcium deposition through matrix GLA protein activation.
- Mood and seasonal resilience support — Vitamin D receptor activity in brain tissue links serum D3 levels to mood regulation and seasonal affective patterns.
- Turmeric Extract for anti-inflammatory support — complements D3’s immune modulation and addresses inflammatory constraints on Vitamin D receptor sensitivity.
£ 15.00
Buy 3 Get 1 Free
Vegetarian
Product Features & Quality Assurance
- • GMP Certified — consistent quality and potency guaranteed across every batch
- • Made in the USA — manufactured to pharmaceutical-grade standards
- • Quality and Potency Guaranteed — no artificial colours, no preservatives
- • Tablet format — easy to chew or swallow, with natural flavour from Xylitol and Stevia
- • Clean formulation — blood-glucose neutral sweeteners, Turmeric Extract, no artificial additives
- • 60 tablets — a full two-month supply at one tablet per day
- Vitamin D deficiency affects an estimated one in five adults in the UK — building silently across months and years before fatigue, low mood, and immune vulnerability become impossible to ignore
- Standard dietary sources and limited UK sunlight cannot maintain the blood levels that immune function, bone health, and hormonal balance require — especially from October through April
- Vitamin D3 at 5,000 IU delivers a therapeutic dose that meaningfully raises deficient levels — where lower-dose supplements often fall short for adults who are already depleted
- Vitamin K2 (as MK-4) is the essential co-factor that directs calcium into bones rather than arteries — the pairing that high-dose D3 supplementation requires for safety and efficacy
- Consistent daily supplementation — one tablet with a meal — produces the blood level optimisation that seasonal sunlight and dietary intake alone cannot sustain year-round
Vitamin D insufficiency is the most prevalent nutritional deficiency in the UK adult population — and the gap between standard low-dose supplementation and genuine blood level optimisation is wider than most people appreciate. You may benefit from D Plus™ if you experience any of the following:
- Persistent fatigue, low energy, or a general sense of reduced vitality that does not resolve with rest.
- Frequent infections, slow immune recovery, or reduced resilience during autumn and winter.
- Low mood, seasonal affective patterns, or reduced motivation that intensifies through the darker months.
- Bone density concerns, muscle weakness, or a history of stress fractures.
- Limited sun exposure due to indoor work, northern UK location, or habitual sun protection use.
- Darker skin tone — which requires significantly longer sun exposure to synthesise equivalent Vitamin D.
- Age over 40, when both skin synthesis efficiency and renal activation of Vitamin D decline.
- A confirmed or suspected Vitamin D deficiency identified through blood testing.
D Plus™ is built around the understanding that Vitamin D optimisation is a two-compound challenge. Raising serum Vitamin D levels with D3 alone addresses one side of the equation. Ensuring that the calcium mobilised by that D3 is directed appropriately requires K2. The formula delivers both at doses that make a measurable difference.
Vitamin D3 at 5,000 IU delivers a therapeutic dose, not a maintenance gesture — The UK government’s standard recommendation of 400 IU is designed to prevent deficiency in the general population, not to optimise function in adults who are already depleted. Research consistently shows that adults with low baseline levels require significantly higher doses to reach the 25(OH)D blood levels — typically 40–60 ng/mL — associated with optimal immune, bone, and hormonal function. At 5,000 IU, D Plus™ provides the dose range that meaningfully moves the needle for deficient adults. This is the gap that 400 IU supplements do not close.
Cholecalciferol is the form that matters for serum level optimisation — Vitamin D3 (cholecalciferol) raises serum 25(OH)D levels approximately three times more effectively than Vitamin D2 (ergocalciferol) at equivalent doses. The difference is not marginal. Studies comparing D2 and D3 supplementation consistently show that D3 produces higher, more stable blood levels and longer-lasting tissue stores. D Plus™ uses cholecalciferol exclusively — the same form the skin produces — ensuring that every 5,000 IU tablet delivers the biological equivalent of meaningful sunlight exposure.
Vitamin K2 MK-4 at 150 mcg directs calcium where it belongs — High-dose Vitamin D3 increases intestinal calcium absorption. Without adequate Vitamin K2, that calcium enters the bloodstream without clear direction — and elevated unbound calcium has been associated with arterial calcification and reduced vascular flexibility. Vitamin K2 activates two critical proteins: osteocalcin, which binds calcium into bone matrix, and matrix GLA protein (MGP), which inhibits calcium deposition in arterial walls. MK-4 is the form with the fastest tissue uptake and the most established mechanistic evidence for this dual protective role.
The D3-K2 combination supports immune regulation beyond bone and calcium — Vitamin D receptors are present in virtually every immune cell type, including T cells, B cells, macrophages, and dendritic cells. Vitamin D3 at optimised serum levels modulates both innate and adaptive immunity — enhancing pathogen defence while reducing the excessive inflammatory responses that drive autoimmune activity. This is the mechanism behind the consistent association between Vitamin D sufficiency and reduced respiratory infection frequency, faster recovery, and lower inflammatory marker levels. K2 contributes independently through its role in reducing vascular inflammation.
Turmeric Extract adds complementary anti-inflammatory support — The inclusion of Turmeric Extract in the D Plus™ formula goes beyond flavouring. Curcumin, the active compound in Turmeric, has well-documented anti-inflammatory activity through its inhibition of NF-κB — a transcription factor central to the inflammatory cascade. In the context of a Vitamin D supplement, this is a meaningful addition: chronic low-grade inflammation impairs Vitamin D receptor sensitivity, reducing the cellular response to D3 even when serum levels improve. Turmeric addresses this receptor-level constraint directly.
Xylitol and Stevia support palatability without blood sugar impact — D Plus™ is formulated as a tablet rather than a capsule, using Xylitol and Stevia as natural sweeteners alongside Natural Flavor. This makes the tablet easy to chew or dissolve if preferred — particularly relevant for adults who have difficulty swallowing capsules. Neither Xylitol nor Stevia raises blood sugar, making D Plus™ suitable for people managing blood glucose levels alongside their Vitamin D supplementation.
Active Ingredients: Vitamin D-3 (as cholecalciferol) 5,000 IU, Vitamin K-2 (as MK-4) 150 mcg.
Other Ingredients: Xylitol, Fructooligosaccharides, Magnesium Stearate, Microcrystalline Cellulose, Natural Flavor, Stevia Extract (leaf), Turmeric Extract.
No artificial colours. No preservatives. Quality and Potency Guaranteed.
Take 1 tablet daily, or as directed by your healthcare professional. For best results, take with a meal containing dietary fat — Vitamin D3 is fat-soluble and absorbs significantly more effectively when consumed alongside fat-containing food. Do not exceed the recommended daily intake unless advised by your doctor.
Do not use if the tamper-evident seal is broken or missing. Keep out of reach of children. Store tightly closed in a cool, dry place.
Warning: Do not use this product if you are pregnant, nursing, or have a history of allergies without first consulting your doctor or other healthcare professional. If you are taking anticoagulant (blood thinning) medications, consult your physician before use as Vitamin K2 interacts with anticoagulant activity.
Serving Size: 1 Tablet | Servings per Container: 60
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D-3 (as cholecalciferol) | 5,000 IU | 1,250% |
| Vitamin K-2 (as MK-4) | 150 mcg | * |
*Daily Value (DV) not established.
Frequently Asked Questions
A: D Plus is a high-strength Vitamin D dietary supplement delivering 5,000 IU of Vitamin D3 (cholecalciferol) combined with 150 mcg of Vitamin K2 (MK-4) per tablet. It is designed to raise and maintain optimal Vitamin D blood levels in adults who are deficient or insufficient u2014 supporting immune function, bone mineralisation, mood stability, and muscle health, particularly during the UKu2019s autumn and winter months when sunlight synthesis is insufficient.
A: Vitamin D3 increases calcium absorption from food. Without adequate Vitamin K2, that additional calcium circulates without clear direction u2014 and has been associated with arterial calcification when left unmanaged. Vitamin K2 (as MK-4) activates two proteins that govern calcium distribution: osteocalcin, which binds calcium into bone matrix, and matrix GLA protein (MGP), which prevents calcium from depositing in arterial walls. At a therapeutic dose of 5,000 IU D3, K2 is not optional u2014 it is the co-factor that makes high-dose D3 supplementation both safe and complete.
A: For most adults, yes u2014 particularly those with confirmed deficiency or insufficiency. The UKu2019s Tolerable Upper Intake Level for Vitamin D is 4,000 IU per day for general supplementation, but clinical evidence supports higher doses in deficient individuals under medical guidance. If you have concerns about your Vitamin D status, a serum 25(OH)D blood test before starting will establish your baseline and allow you and your healthcare provider to determine the appropriate dose for your individual situation. People with certain conditions including hypercalcaemia or granulomatous disorders should not supplement at high doses without medical supervision.
Vitamin D3 (cholecalciferol) is the form the skin produces during sunlight exposure and is the form used in D Plus. Research consistently shows that D3 raises serum 25(OH)D levels approximately three times more effectively than D2 (ergocalciferol) at equivalent doses, and produces more stable, longer-lasting blood levels. D2 is plant-derived and used in some supplements and fortified foods u2014 but for therapeutic blood level optimisation, D3 is the clinically superior form.
A: Take one tablet daily with a meal containing dietary fat u2014 morning is the most practical anchor for most people. Vitamin D3 is fat-soluble and requires dietary fat for optimal intestinal absorption. Taking it on an empty stomach or with a fat-free meal can significantly reduce the amount absorbed. Morning dosing also avoids the rare possibility that high-dose Vitamin D taken late in the day may interact with melatonin production and affect sleep quality.
A: With consistent daily supplementation at 5,000 IU, most adults see a meaningful rise in serum 25(OH)D within four to eight weeks. Reaching optimal levels u2014 typically 40 - 60 ng/mL -- from a significantly deficient baseline may take two to three months of consistent use. The rate of increase depends on your starting level, body weight, dietary fat intake at the time of dosing, and individual absorption efficiency. A follow-up blood test at three months gives you an accurate picture of your response.
A: The Vitamin D3 (cholecalciferol) in D Plus is derived from lanolin (sheep wool), which is an animal-derived source. D Plus is therefore not suitable for vegans. Vegetarians who consume animal by-products may consider it acceptable u2014 but should review the source if this is a concern. The tablet shell and other ingredients are plant-derived.
A: D Plus is available directly from Care & Cure Nutraceuticals at www.careandcure.co.uk. It is manufactured in the USA to GMP-certified standards and dispatched from London, UK.
Customer Reviews
5.0
4 reviews
10 March 2026
After trying several Vitamin D3 supplements with weak results, I finally found one that actually works. **D Plus Vitamin D3** has made a noticeable difference for me. The results have been much better compared to other supplements I’ve used, and I’m very satisfied with it. If you’re looking for an effective Vitamin D3 supplement, this one is definitely worth trying.
✅ Verified Purchase
25 October 2024
Works wonders for my energy levels!" "Honestly, I never knew a supplement could make this much of a difference. Since I started taking D Plus, I’ve felt more energetic and just generally healthier. This is a must for anyone looking to boost their immune system, especially with UK winters
✅ Verified Purchase
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